Nineteen of the Russian's twenty-one championships have been achieved on hard surfaces
A comeback Medvedev secured his first title for 882 days with a win over Corentin Moutet in the tournament championship match.
The athlete, a ex- number one, has experienced a torrid season, achieving just one match at the major tournaments and experiencing a meltdown at the US Open.
The player's unpredictability on the professional circuit - and difficulties with his serve in specific - caused him exiting of the world's top 10 and finally parting ways with former mentor his previous coach.
Presently collaborating with his coach and his other coach, Medvedev has gradually improved in the past month - climaxing in a closely contested three-set victory over Frenchman Corentin Moutet.
This represents Medvedev's first title after the Italian tournament and first on a hard surface from spring of the previous year.
Success also indicates he has achieved twenty-one titles at 21 different competitions.
"For the first time I'm at a competition with my children at once, so to win a title is really nice," commented world number 14 the champion.
"This title is in dedication of my child my daughter, because the maiden victory I won when my older daughter her name was delivered was for her."
Medvedev, the former major winner, had been defeated in his previous six championship matches, including in Halle in the past months.
His retrieving play style and recurring emotional displays on the tennis court had caused some to question if his skill to play at the elite level was over.
However the athlete has implemented adjustments in the past month, striving to advance forward and perform assertively, backed up by an better serving game.
The champion fought back from a deficit in the initial set against the challenging opponent, taking four of the last five exchanges to go ahead.
The competitors traded service breaks in the second set before the Frenchman, attempting for his maiden professional title, gained dominance to push for a third set.
Moutet saved 4 early-game opportunities in a competitive third set before the Russian won the break to fifteen to close out the victory.
Appropriately, the winner earned the title with a point at the front of the court, with the Frenchman unable to manage a volley after over two and a half hours.